Area.size.shape features

Description

Area.size.shape features characterize the geometric properties and spatial extent of segmented objects. these measurements are computed using both mesh and voxel-based approaches.

Features extracted

Area.size.shape feature measurements

Feature	description
VOLUME	total volume of the segmented object in voxels
CENTER.X	X-coordinate of object centroid
CENTER.Y	Y-coordinate of object centroid
CENTER.Z	Z-coordinate of object centroid
BBOX.VOLUME	volume of the bounding box containing the object
MIN.X / MAX.X	minimum and maximum X coordinates
MIN.Y / MAX.Y	minimum and maximum Y coordinates
MIN.Z / MAX.Z	minimum and maximum Z coordinates
EXTENT	ratio of object volume to bounding box volume
EULER.NUMBER	euler characteristic (topological descriptor)
EQUIVALENT.DIAMETER	diameter of a sphere with equivalent volume
SURFACE.AREA	total surface area of the 3D object

Calculation method

These features use 3D mesh reconstruction and voxel analysis:

Mesh generation: create 3D surface mesh from voxel boundaries
Volume calculation: sum voxels within segmented region
Surface analysis: compute surface area from mesh triangulation
Spatial statistics: calculate centroid and bounding box properties

Applications

Area.size.shape features are useful for:

Quantifying cell and organoid growth
Detecting morphological abnormalities
Comparing size distributions across conditions
Identifying fusion or fragmentation events